Novel optical techniques for enhanced structural, functional and dynamical imaging of anterior and posterior segments of the eye. (TEAM FNP)
Project co-financed by the European Regional Development Fund under the Operational Programme Innovative Economy.
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Description This program is a multidisciplinary effort which integrates fundamental studies, applied optics, new technology development, engineering and ophthalmology, giving perspective for practical use of obtained results in medical diagnostics and biology. The general scope of this proposal is related to thematic areas of Techno and Bio via the development of new optical technologies and by their potential applications to medical diagnostics. We assume that this particular project will enable to conduct research at the highest standards, giving significance and novel findings in fundamental optical studies, as well as in the field of applied optics and engineering, with further perspective for commercialization of obtained results. Research and engineering work of the project is conducted in 3 new laboratories of Optical Biomedical Imaging Group (OBIG – former Medical Physics Group) at Nicolaus Copernicus University (NCU), Toruń. Objectives and specific aims The project consists of two independent parts. The objective of the first part is to broaden knowledge about the dynamic optical processes in the human retina, especially these based on auto-fluorescence of retinal tissue, to develop novel ultrahigh resolution, optical imaging modality for visualization of morphology and function of the human retina. The objective of the second part of the project is to develop new, high performance imaging technology, that will have widespread research and clinical applications, to elucidate changes in morphology and biomechanical properties of the anterior segment of the human eye, and to develop and demonstrate new methods for visualization, mapping and morphometry, which can improve diagnostic sensitivity and the assessment of disease progression. Financial Support The project is financed by TEAM programme of The Foundation for Polish Science (FNP), which is an independent, self-financing, non-profit, non-governmental organization, with a mission of supporting science in Poland. It is the largest source of science funding in Poland outside the state budget
Karol Karnowski, PhD Maciej Szkulmowski, PhD Krzysztof Szulżycki, PhD Student Dominik Charczun, MSc Agnieszka Zielińska MSc, Magdalena Urbańska, MSc Bartosz Pałucki, MSc Eng Krzysztof Maliszewski, MSc Eng Marta Motoczyńska (Kustra), BEng
Fundus autofluorescence imaging and two photon processes in native dyes in human eye.
We are looking for specific reactions of native fluorophores on light. Mostly we focus on excited state dynamics of lipofuscin. In order to distinguish between flurophores in fundus, we put effort to perform fundus imaging relied on pump and probe scheme. Together with fundus imaging, we perform spectral analysis of lipofuscins, especially excited state transmission measurements. FAF images of fundus taken with our device, with extremely low intensity of excitation beam. All presented images are single frames, without averaging.